THE brother of Wangaratta woman Kath Bergamin, who disappeared and was "unlawfully killed" 21 years ago today, believes it's time authorities pursue any suspects through the courts in a final bid for justice for his sister.

Roger Russell, along with his 95-year-old mother Margaret, want Victoria Police and the Office of Public Prosecutions to charge the person or persons they believe are responsible for Kath's disappearance and death.

Kath was 37 years old at the time of her disappearance from her Brien Crescent home on August 18, 2002 and her body has never been found.

A coronial inquest in 2008 found Ms Bergamin had been "forced to leave" her home and "unlawfully killed", but concluded there was "insufficient evidence" to establish the person or persons responsible.

In September 2020, investigators interviewed five people in connection with her disappearance, however, all were released pending further enquiries.

No charges have been laid.

Speaking to the Wangaratta Chronicle on the eve of the anniversary, Mr Russell said the time is now to charge the person or persons Victoria Police believe are responsible.

"We want a court case to run with whatever evidence is available at this stage due to the fact there has been a long passing of time and the people could pass away and witnesses are passing away," Mr Russell said.

"There's not going to be much more new evidence so we're keen at this point to see the case brought to court.

"It is a question of evidence and we think if it goes to court there is a chance for more to come out.

"We would like the matter settled and I can't see how the passing of any more time is going to help anybody involved in the whole sad affair.

"We would like to see a case run and tested, and if it fails it fails, but if it gets up we might get some answers and actually get to find where Kath is, because someone knows where she is."

The Wangaratta Chronicle has published many articles about the case, it's been in a book and several podcasts have been aired.

"A fair few people have looked at the case and most of them end up saying why hasn't it gone to court," Mr Russell said.

Detective Inspector Dave Dunstan from the Missing Persons Squad told the Wangaratta Chronicle their "thoughts are with the family and loved ones of Kath Bergamin on the anniversary of her disappearance".

Detectives from the Missing Person Squad continue to appeal for information, no matter how small that piece of information may seem.

Det Insp Dunstan said while 21 years have now passed, police have not given up hope of finding Kath and determining who is responsible for her death.

"We remain committed to solving this case and providing some comfort and closure to Kath’s loved ones and the local community," he said.

"Investigators understand how difficult this time of year is for Kath’s family and friends and we acknowledge the grief and sadness they continue to feel even after two decades.

"It remains our hope that one day we are able to provide them with the answers they so deeply deserve."

A $1 million reward also remains on offer for information leading to the apprehension and subsequent conviction of the person or persons responsible for Kath’s death.

Anyone with information is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report at www.crimestoppers.com.au.