A man has been airlifted to hospital following a single vehicle crash on Oxley Flats Road near Wangaratta on Tuesday morning.

CFA responded to reports of a vehicle accident near Oxley at around 7:37am.

Three CFA units responded alongside SES, FRV, Victoria Police and Ambulance Victoria.

Upon arrival crews found a single vehicle had crashed at the approach to a bridge.

CFA supported SES crews to extricate one occupant, believed to be a man in his 20s.

Ambulance Victoria said a specialist air ambulance helicopter as well as Mobile Intensive Care Ambulance (MICA) and Advanced Life Support (ALS) paramedic crews responded to the scene.

A Victoria Police spokesperson said the male driver and sole occupant of the car which had crashed into the bridge was airlifted to the Alfred Hospital with non-life-threatening injuries.