Police arrested a woman and will speak with a man following the seizure of drugs and prohibited weapons at a Wangaratta home.

A Wangaratta police spokesperson said detectives executed a search warrant of a Higgins Street home on Wednesday and seized an imitation firearm, prohibited weapons and drugs.

A 30-year-old woman was arrested and released pending further enquiries, and a 24-year-old man was set to be spoken to by police.